Functional Haplotypes That Produce Normal Ficolin‐2 Levels Protect against Clinical Leprosy

descriptionPublicationkeyboard_double_arrow_right Article 15 Mar 2009 English Publisher:Oxford University Press (OUP)Journal:The Journal of Infectious Diseases, volume 199, pages 801-804 (issn: 0022-1899, eissn: 1537-6613,

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Authors: Iara, de Messias-Reason; Peter G, Kremsner; Jürgen F J, Kun;

doi: 10.1086/597070

pmid: 19434912

Functional Haplotypes That Produce Normal Ficolin‐2 Levels Protect against Clinical Leprosy

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Abstract

Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule. A total of 158 patients with leprosy and 210 healthy control subjects from Brazil were investigated. Polymorphisms in the promoter and exon 8 of FCN2 were assessed by DNA sequencing. The distribution of functional FCN2 haplotypes amongpatients was significant different from that among the control subjects (P = .004). These results unveil an immunogenetic role for ficolin-2 in the host response against M. leprae.

Related Organizations

University of Tübingen
Germany
State University of West Paraná
Brazil

Keywords

Polymorphism, Genetic, Chromosome Mapping, Genes, Recessive, Exons, Ficolins, Haplotypes, Reference Values, Lectins, Leprosy, Humans, Promoter Regions, Genetic, DNA Primers, Genes, Dominant

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