Hepatotoxicity of Rifampin-Pyrazinamide and Isoniazid Preventive Therapy and Tuberculosis Treatment
Copyright policy )Hepatotoxicity of Rifampin-Pyrazinamide and Isoniazid Preventive Therapy and Tuberculosis Treatment
Severe liver injury has been attributed to preventive treatment of latent tuberculosis infection with a 2-month course of rifampin-pyrazinamide.A retrospective cohort study in The Netherlands compared the hepatotoxicity of preventive treatment with rifampin-pyrazinamide with that of preventive treatment with isoniazid, and also with that of treatment for active tuberculosis containing at least isoniazid, rifampin, and pyrazinamide.Preventive treatment with rifampin-pyrazinamide caused severe hepatotoxicity more often than did preventive treatment with isoniazid (odds ratio [OR], 2.61; 95% confidence interval [CI], 1.26-5.39; P=.012), especially in patients or =30 mg/kg. Preventive treatment with rifampin-pyrazinamide was more hepatotoxic even when the advised pyrazinamide dose of up to 20 mg/kg for preventive treatment was compared with the pyrazinamide dose of 30 mg/kg for tuberculosis treatment.Preventive treatment with rifampin-pyrazinamide causes severe hepatotoxicity more often than does preventive treatment with isoniazid or curative treatment for tuberculosis.
- KNCV TB Plus Netherlands
- Radboud University Nijmegen Netherlands
- Amsterdam UMC, location AMC Netherlands
- University of Amsterdam Netherlands
- Amsterdam UMC Netherlands
Adult, Male, Adolescent, Middle Aged, Pyrazinamide, Anti-Bacterial Agents, Cohort Studies, Treatment Outcome, Isoniazid, Humans, Tuberculosis, Drug Therapy, Combination, Female, Prospective Studies, Chemical and Drug Induced Liver Injury, Rifampin, Antibiotics, Antitubercular, Netherlands, Retrospective Studies
Adult, Male, Adolescent, Middle Aged, Pyrazinamide, Anti-Bacterial Agents, Cohort Studies, Treatment Outcome, Isoniazid, Humans, Tuberculosis, Drug Therapy, Combination, Female, Prospective Studies, Chemical and Drug Induced Liver Injury, Rifampin, Antibiotics, Antitubercular, Netherlands, Retrospective Studies
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