Effects of Total Body Irradiation and Cyclosporin A on the Lethality of Toxic Shock Syndrome Toxin–1 in a Rabbit Model of Toxic Shock Syndrome

descriptionPublicationkeyboard_double_arrow_right Article 15 Oct 2003 English Publisher:Oxford University Press (OUP)Journal:The Journal of Infectious Diseases, volume 188, pages 1,142-1,145 (issn: 0022-1899, eissn: 1537-6613,

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Authors: Martin M, Dinges; Dale S, Gregerson; Timothy J, Tripp; John K, McCormick; Patrick M, Schlievert;

doi: 10.1086/378514

pmid: 14551884

Effects of Total Body Irradiation and Cyclosporin A on the Lethality of Toxic Shock Syndrome Toxin–1 in a Rabbit Model of Toxic Shock Syndrome

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Abstract

Toxic shock syndrome (TSS) may be mediated by superantigen-activated T cells, a theory we tested in rabbits, which are more susceptible to the lethal effects of superantigens, such as TSS toxin-1 (TSST-1), than are mice. Rabbits exposed to 10 cGy of total body irradiation exhibited T cell deficiency, with profound depletion of splenic lymphocytes and circulating CD4(+) lymphocytes, as well as an inability to manifest delayed-type hypersensitivity. Nevertheless, these rabbits remained completely susceptible to TSST-1, indicating that TSS can occur in the setting of marked immunosuppression.

Related Organizations

University of Minnesota
United States
University of Minnesota Morris
United States

Keywords

Immunosuppression Therapy, Mice, Inbred BALB C, Staphylococcus aureus, Superantigens, T-Lymphocytes, Bacterial Toxins, Staphylococcal Infections, Shock, Septic, Enterotoxins, Mice, Cyclosporine, Animals, Female, Rabbits, Immunosuppressive Agents, Whole-Body Irradiation

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