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Antifungal Resistance in Pathogenic Fungi

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2002 English Publisher:Oxford University Press (OUP)Journal:Clinical Infectious Diseases, volume 35, pages 1,073-1,080 (issn: 1058-4838, eissn: 1537-6591,

Authors: Sofia Perea; Thomas F. Patterson; Thomas F. Patterson;

doi: 10.1086/344058

pmid: 12384841

Antifungal Resistance in Pathogenic Fungi

- Summary
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Abstract

Pathogenic fungi are the cause of life-threatening infections in an increasing number of immunocompromised patients. The intrinsic resistance to antifungal therapy observed in some genera, along with the development of resistance during treatment in others, is becoming a major problem in the management of these diseases. We reviewed the epidemiology of the most common systemic fungal infections for which antifungal resistance is a potential problem, the mechanisms of antifungal resistance, the correlation between in vitro susceptibility testing and clinical outcome, and the clinical implications of antifungal resistance.

Related Organizations

South Texas Veterans Health Care System
United States
The University of Texas Health Science Center at San Antonio
United States
Murphy Oil
United States

Keywords

Antifungal Agents, Candidiasis, Flucytosine, Microbial Sensitivity Tests, Immunocompromised Host, Treatment Outcome, Drug Resistance, Fungal, Amphotericin B, Prevalence, Aspergillosis, Humans, Candida, Forecasting

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	226
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%