Human Cytomegalovirus (HCMV) Replication Dynamics in HCMV‐Naive and ‐Experienced Immunocompromised Hosts
Copyright policy )Human Cytomegalovirus (HCMV) Replication Dynamics in HCMV‐Naive and ‐Experienced Immunocompromised Hosts
Human cytomegalovirus (HCMV) can infect both HCMV-naive and -experienced transplant patients. In this study, the growth rate of HCMV in HCMV-naive hosts (1.82 units/day; 95% confidence interval [CI], 1.44-2.56 units/day) was shown to be significantly faster than the growth rate of virus in HCMV-experienced hosts undergoing recurrent infection (0.61 units/day; 95% CI, 0.55-0.7 units/day; P93% (95% CI, 89%-98%) is required to eliminate viral growth during infection of HCMV-naive liver transplant recipients, whereas lower efficacy levels are sufficient to reduce the R(0) value to <1 in hosts with prior HCMV immunity.
- University College London United Kingdom
AIDS-Related Opportunistic Infections, Cytomegalovirus Infections, DNA, Viral, Cytomegalovirus, Humans, Virus Replication, Liver Transplantation
AIDS-Related Opportunistic Infections, Cytomegalovirus Infections, DNA, Viral, Cytomegalovirus, Humans, Virus Replication, Liver Transplantation
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