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The American Journal of Human Genetics
Article
License: Elsevier Non-Commercial
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The American Journal of Human Genetics
Article . 2000
License: Elsevier Non-Commercial
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The American Journal of Human Genetics
Article . 2000 . Peer-reviewed
License: Elsevier Non-Commercial
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Gamete-Competition Models

Authors: Sinsheimer, Janet S.; Blangero, John; Lange, Kenneth;

Gamete-Competition Models

Abstract

The gamete-competition model is an application of the Bradley-Terry model for ranking of sports teams. If allele i of a marker locus is assigned parameter taui>0, then the probability that a parent with heterozygous genotype i/j transmits allele i is Pr(i/j-->)=tau(i)/(tau(i) + tau(j). Mendelian segregation corresponds to the choice tau(i)=1 for all i. To test whether Mendelian segregation is true, one can estimate the tau(i) from pedigree data and perform a likelihood-ratio test under the constraint that one tau(i) equals 1. Although this procedure generates an interesting method for performance of segregation analysis with a marker locus, its real promise lies in generalization of the transmission/disequilibrium test. Quantitative as well as qualitative outcomes can be considered. The gamete-competition model uses full pedigree data and gives an estimate of the strength of transmission distortion to affected children for each allele. Covariates are incorporated by rewriting of tau(i)=exp(beta(t)x(k)), where beta is a parameter vector and xk is a covariate vector for the kth transmitted gamete. Examples of covariates include disease-severity indicators for the child, sex of the child, or repeat number for tandem-repeat alleles.

Keywords

Male, Parents, Heterozygote, Potassium Channels, Peptidyl-Dipeptidase A, Linkage Disequilibrium, Association, Gene Frequency, Genetics, Humans, Genetics(clinical), Gamete, competition, Alleles, Likelihood Functions, Models, Genetic, Genetic Diseases, Inborn, Chromosome Mapping, Phosphoproteins, Pedigree, Bradley-Terry model, Germ Cells, Diabetes Mellitus, Type 2, Phosphoglucomutase, ATP-Binding Cassette Transporters, Female, Transmission/disequilibrium test(s)

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
50
Average
Top 10%
Top 10%
hybrid