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The American Journal of Human Genetics
Article
License: Elsevier Non-Commercial
Data sources: UnpayWall
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The American Journal of Human Genetics
Article . 1998
License: Elsevier Non-Commercial
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The American Journal of Human Genetics
Article . 1998 . Peer-reviewed
License: Elsevier Non-Commercial
Data sources: Crossref
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Nuclear Transport: Run by Ran?

Authors: Dasso, Mary; Pu, Robert T.;

Nuclear Transport: Run by Ran?

Abstract

A distinguishing feature of eukaryotic cells is the compartmentalization of their DNA within the nucleus. The sequestration of the genetic material away from the translational machinery and cytosolic proteins has at least two obvious but important implications: First, there must be a mechanism whereby the separate identities of the nucleus and cytosol are established and maintained within each cell cycle. The existence of such a mechanism was confirmed by the finding that many karyophilic proteins have nuclear localization sequences (NLS) (Gorlich and Mattaj 1996).

Keywords

Cell Nucleus, Xenopus, Nuclear Proteins, Biological Transport, Models, Biological, Ran, ran GTP-Binding Protein, Importin(s), GTP-Binding Proteins, Nuclear transport, Genetics, Animals, Humans, Genetics(clinical)

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
26
Top 10%
Top 10%
Top 10%
hybrid