Observations are discussed which show that the Na I/H2 column-density ratio is relatively constant among different clouds where H2 is optically thin, but the Na I/Ca II column-density ratio varies. This implies that the gas-phase abundance of calcium is variable. It is proposed that the wide variation in the gas-phase calcium abundance can be explained by small variations in the calcium content of grains. The observed enhancement of the Ca II/Na I column-density ratio with cloud velocity is attributed to grain destruction in grain-grain collisions within the same cloud. The structure of shock waves propagating through the interstellar gas is computed, and the grain-destruction model is compared with observational data.