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Interferon and Interferon Inducers in the Treatment of Malignancies

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1970Publisher:Rockefeller University PressJournal:The Journal of General Physiology, volume 56, pages 238-248 (issn: 0022-1295, eissn: 1540-7748,

Authors: Hilton B. Levy; Freddie L. Riley; Sam Margolis;

doi: 10.1085/jgp.56.1.238

pmid: 19873670

pmc: PMC2225867

Interferon and Interferon Inducers in the Treatment of Malignancies

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Abstract

The mechanism of the antitumor action of polyinosinic-polycytidylic acid is probably multifaceted. The compound induces the synthesis of interferon, and interferon probably is active against some tumors. Poly I:poly C alters protein and RNA synthesis in tissue culture. It specifically inhibits such macromolecule synthesis in tumors in vivo, while having less inhibitory action on synthesis in normal organs, or it may actually enhance. Finally, poly I:poly C strongly enhances graft vs. host rejection mechanisms, which may play a role in the rejection of some tumors.

Related Organizations

National Institutes of Health
United States
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National Institute of Allergy and Infectious Diseases
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