
doi: 10.1084/jem2013iti3
Two adaptor proteins prevent cells from overreacting to bacterial lipopolysaccaride (LPS), report Shinohara et al. on page 333. Dok-1 and Dok-2 dampen intracellular signals from the LPS receptor, Toll-like receptor 4 (TLR4), which may help explain how cells mount a potent response to invading bacteria without also triggering destructive inflammatory responses.
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