Antiviral defense: interferons and beyond

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 31 Jul 2006 English Publisher:Rockefeller University PressJournal:The Journal of Experimental Medicine, volume 203, pages 1,837-1,841 (issn: 0022-1007, eissn: 1540-9538,

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Authors: Stetson, Daniel B.; Medzhitov, Ruslan;

doi: 10.1084/jem.20061377

pmid: 16880263

pmc: PMC2118364

Antiviral defense: interferons and beyond

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Abstract

Mice lacking the adaptor protein that initiates an antiviral response downstream of the RNA helicases retinoic acid–inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) have recently been described. These studies highlight the essential and nonredundant role of nucleic acid recognition in the induction of type I interferon production and raise important questions regarding the nature of cell-autonomous virus detection in coordinating the antiviral response.

Related Organizations

Howard Hughes Medical Institute
United States
Yale University
United States

Keywords

Mice, Commentaries, Nucleic Acids, Interferon Type I, Animals, Antiviral Agents, Adaptor Proteins, Signal Transducing

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