descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1988 English Publisher:Rockefeller University PressJournal:The Journal of experimental medicine, volume 167, pages 1,511-1,516 (issn: 0022-1007, eissn: 1540-9538,

Authors: S Isaaz; P Seckinger; J M Dayer;

doi: 10.1084/jem.167.4.1511

pmid: 2833558

pmc: PMC2188924

A human inhibitor of tumor necrosis factor alpha.

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Abstract

Urine of some febrile patients exhibits a TNF-alpha inhibitory activity (TNF-alpha INH), sensitive to heat and trypsin, with an apparent mol wt of 40-60 X 10(3) and a pI range of 5.5-6.1. As for the Il-1 INH, the TNF INH activity involves a competitive mechanism of action suggesting the existence of a family of negative feedback-regulating molecules interfering with cytokines actions.

Related Organizations

University Hospital of Geneva
Switzerland

Keywords

Fever, Myositis, Tumor Necrosis Factor-alpha, Urine, Molecular Weight, L Cells, Sepsis, Chromatography, Gel, Humans, Histiocytic Sarcoma, Carcinoma, Small Cell

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