Retromer revisited: Evolving roles for retromer in endosomal sorting
Copyright policy )Retromer revisited: Evolving roles for retromer in endosomal sorting
The highly conserved retromer complex has been linked to cargo retrieval from endosomes to the trans-Golgi network. In this issue, Kvainickas et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702137) and Simonetti et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703015) fundamentally question the current retromer model and demonstrate that in mammalian cells, the individual retromer subcomplexes have functionally diverged to organize multiple distinct sorting pathways.
- Boston College United States
- Boston University United States
Protein Transport, Commentary, Vesicular Transport Proteins, Animals, Biological Transport, Endosomes, Sorting Nexins, trans-Golgi Network
Protein Transport, Commentary, Vesicular Transport Proteins, Animals, Biological Transport, Endosomes, Sorting Nexins, trans-Golgi Network
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