Axon degeneration: Linking axonal bioenergetics to myelin
Copyright policy )Axon degeneration: Linking axonal bioenergetics to myelin
The mechanisms by which axonal degeneration occurs, even in the presence of apparently normal myelin sheaths, remain unknown. In this issue, Yin et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607099) study mutant mice in which proteolipid protein is replaced by the peripheral myelin protein P0 and describe a number of early axonal abnormalities, which together suggest that aberrant mitochondrial energy metabolism precedes axonal degeneration.
- University at Buffalo, State University of New York United States
- State University of New York at Potsdam United States
Axonal Transport, Mitochondrial Dynamics, Models, Biological, Axons, Mice, Mutant Strains, Mitochondria, Oligodendroglia, Nerve Degeneration, Commentary, Animals, Energy Metabolism, Myelin Sheath
Axonal Transport, Mitochondrial Dynamics, Models, Biological, Axons, Mice, Mutant Strains, Mitochondria, Oligodendroglia, Nerve Degeneration, Commentary, Animals, Energy Metabolism, Myelin Sheath
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