HMGB2 holds the key to the senescence-associated secretory phenotype
Copyright policy )HMGB2 holds the key to the senescence-associated secretory phenotype
The senescence-associated secretory phenotype (SASP) is a hallmark of senescence with an important physiological impact, but how it is established is unclear. In this issue, Aird et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201608026) describe how chromatin-bound HMGB2 fine tunes SASP expression by avoiding heterochromatin spreading.
- Imperial College London United Kingdom
- Medical Research Council United Kingdom
Secretory Pathway, 610, Down-Regulation, 11 Medical And Health Sciences, Cell Cycle Checkpoints, 06 Biological Sciences, Models, Biological, Chromatin, Phenotype, 616, Commentary, HMGB2 Protein, Humans, Cellular Senescence, Developmental Biology
Secretory Pathway, 610, Down-Regulation, 11 Medical And Health Sciences, Cell Cycle Checkpoints, 06 Biological Sciences, Models, Biological, Chromatin, Phenotype, 616, Commentary, HMGB2 Protein, Humans, Cellular Senescence, Developmental Biology
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