Spatial resolution of cAMP signaling by soluble adenylyl cyclase
Copyright policy )Spatial resolution of cAMP signaling by soluble adenylyl cyclase
G protein–coupled receptor signaling starts at the plasma membrane and continues at endosomal stations. In this issue, Inda et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512075) show that different forms of adenylyl cyclase are activated at the plasma membrane versus endosomes, providing a rationale for the spatial encoding of cAMP signaling.
- University of Milan Italy
Endosomes, Models, Biological, Receptors, G-Protein-Coupled, Adenylyl Cyclases; Animals; Cyclic AMP; Endosomes; Humans; Models, Biological; Receptors, G-Protein-Coupled; Solubility; Signal Transduction; Cell Biology, Solubility, Commentary, Cyclic AMP, Animals, Humans, Adenylyl Cyclases, Signal Transduction
Endosomes, Models, Biological, Receptors, G-Protein-Coupled, Adenylyl Cyclases; Animals; Cyclic AMP; Endosomes; Humans; Models, Biological; Receptors, G-Protein-Coupled; Solubility; Signal Transduction; Cell Biology, Solubility, Commentary, Cyclic AMP, Animals, Humans, Adenylyl Cyclases, Signal Transduction
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