MST kinases in development and disease
Copyright policy )MST kinases in development and disease
The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called STK3), MST3 (also called STK24), MST4, and YSK1 (also called STK25 or SOK1). MST kinases are emerging as key signaling molecules that influence cell proliferation, organ size, cell migration, and cell polarity. Here we review the regulation and function of these kinases in normal physiology and pathologies, including cancer, endothelial malformations, and autoimmune disease.
- The Francis Crick Institute United Kingdom
Model organisms, Reviews, Embryonic Development, Protein Serine-Threonine Kinases, Gene Expression Regulation, Enzymologic, Autoimmune Diseases, Substrate Specificity, Imaging, Fungal Proteins, Signalling & Oncogenes, Cell Movement, Neoplasms, Animals, Humans, Cell Proliferation, Computational & Systems Biology, Chemical Biology & High Throughput, Cell Polarity, Gene Expression Regulation, Developmental, Organ Size, Cell Biology, Tumour Biology, Endothelium, Vascular, Signal Transduction, Developmental Biology
Model organisms, Reviews, Embryonic Development, Protein Serine-Threonine Kinases, Gene Expression Regulation, Enzymologic, Autoimmune Diseases, Substrate Specificity, Imaging, Fungal Proteins, Signalling & Oncogenes, Cell Movement, Neoplasms, Animals, Humans, Cell Proliferation, Computational & Systems Biology, Chemical Biology & High Throughput, Cell Polarity, Gene Expression Regulation, Developmental, Organ Size, Cell Biology, Tumour Biology, Endothelium, Vascular, Signal Transduction, Developmental Biology
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