Reductionism at the vertebrate kinetochore

descriptionPublicationkeyboard_double_arrow_right Article , Conference object 31 Dec 2012 Portugal English Publisher:Rockefeller University PressJournal:Journal of Cell Biology, volume 200, pages 7-8 (issn: 0021-9525, eissn: 1540-8140,

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Authors: Stankovic, Ana; Jansen, Lars E.T.;

doi: 10.1083/jcb.201212005

pmid: 23277428

pmc: PMC3542803

handle: 10400.7/482 , 10400.7/610

Reductionism at the vertebrate kinetochore

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Abstract

The kinetochore forms the site of attachment for mitotic spindle microtubules driving chromosome segregation. The interdependent protein interactions in this large structure have made it difficult to dissect the function of its components. In this issue, Hori et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201210106) present a novel and powerful methodology to address the sufficiency of individual proteins for the creation of a functional de novo centromere.

Country

Portugal

Related Organizations

Gulbenkian Institute for Molecular Medicine
Portugal
Calouste Gulbenkian Foundation
Portugal
Instituto Gulbenkian de Ciência
Portugal

Keywords

DNA-Binding Proteins, Chromosomal Proteins, Non-Histone, Multiprotein Complexes, Reviews, Animals, Kinetochores, Autoantigens, Centromere Protein A

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