HDM2 ERKs PCNA
Copyright policy )HDM2 ERKs PCNA
In this issue, a study by Groehler and Lannigan (2010. J. Cell Biol. doi:10.1083/jcb.201002124) sheds light on the regulation of proliferating cell nuclear antigen (PCNA) turnover and how it is counteracted by the small chromatin-bound kinase ERK8 (extracellular signal-regulated kinase 8). Importantly, inactivation of ERK8 results in genome instability and is associated with cell transformation.
- University of Minnesota United States
- University of Minnesota System United States
- University of Minnesota Morris United States
Cell Transformation, Neoplastic, Proliferating Cell Nuclear Antigen, Reviews, Humans, Proto-Oncogene Proteins c-mdm2, Extracellular Signal-Regulated MAP Kinases, Chromatin, Genomic Instability, DNA Damage, Protein Binding
Cell Transformation, Neoplastic, Proliferating Cell Nuclear Antigen, Reviews, Humans, Proto-Oncogene Proteins c-mdm2, Extracellular Signal-Regulated MAP Kinases, Chromatin, Genomic Instability, DNA Damage, Protein Binding
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