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Revisiting the role of heterochromatin protein 1 in DNA repair

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 18 May 2009 English Publisher:Rockefeller University PressJournal:Journal of Cell Biology, volume 185, pages 573-575 (issn: 0021-9525, eissn: 1540-8140, Copyright policy )
Authors: Ball, Alexander R; Yokomori, Kyoko;

doi: 10.1083/jcb.200904033

pmid: 19451270

pmc: PMC2711565

Revisiting the role of heterochromatin protein 1 in DNA repair

Abstract

Heterochromatin protein 1 (HP1) is a conserved factor critical for heterochromatin organization and gene silencing. It is recruited to chromatin by its direct interaction with H3K9me (methylated lysine 9 residue of histone H3), an epigenetic mark for silenced chromatin. Now, Luijsterburg et al. (Luijsterburg, M.S., C. Dinant, H. Lans, J. Stap, E. Wiernasz, S. Lagerwerf, D.O. Warmerdam, M. Lindh, M.C. Brink, J.W. Dobrucki, et al. 2009. J. Cell Biol. 185:577–586) reveal a new H3K9me-independent role for HP1 in the DNA damage response, which is distinct from the one recently reported by Ayoub et al. (Ayoub, N., A.D. Jeyasekharan, J.A. Bernal, and A.R. Venkitaraman. 2008. Nature. 453:682–686).

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Keywords

Biomedical and clinical sciences, DNA Repair, Chromosomal Proteins, Non-Histone, 1.1 Normal biological development and functioning, Reviews, Non-Histone, Biological Sciences, Medical and Health Sciences, Chromosomal Proteins, Histones, Biological sciences, Underpinning research, Chromobox Protein Homolog 5, Genetics, Animals, Humans, Biochemistry and Cell Biology, Generic health relevance, Developmental Biology

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    popularity
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
26
Top 10%
Top 10%
Top 10%
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