Going in GTP cycles in the nucleolus
Copyright policy )Going in GTP cycles in the nucleolus
Proteins are directed to cellular compartments by specific localization signals. A GTP-driven cycle has now been identified as a mechanism for protein targeting to the nucleolus. The involvement of a GTP switch suggests that nucleolar localization can be regulated and may be responsive to extracellular stimuli via signaling pathways. The uncovered mechanism also implies that localization is determined by increased retention rather than directed targeting.
- National Institute of Health Pakistan
- National Institutes of Health United States
- National Cancer Institute United States
Cell Nucleus, Reviews, Nuclear Proteins, Models, Biological, Protein Transport, GTP-Binding Proteins, Humans, Guanosine Triphosphate, Intranuclear Space, Carrier Proteins, Cell Nucleolus, Cell Proliferation, Protein Binding, Signal Transduction
Cell Nucleus, Reviews, Nuclear Proteins, Models, Biological, Protein Transport, GTP-Binding Proteins, Humans, Guanosine Triphosphate, Intranuclear Space, Carrier Proteins, Cell Nucleolus, Cell Proliferation, Protein Binding, Signal Transduction
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