Anthrax toxin rafts into cells

descriptionPublicationkeyboard_double_arrow_right Article 03 Feb 2003 English Publisher:Rockefeller University PressJournal:The Journal of Cell Biology, volume 160, pages 295-296 (issn: 0021-9525, eissn: 1540-8140,

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Authors: Kurzchalia, T.;

doi: 10.1083/jcb.200301032

pmid: 12566425

pmc: PMC2172653

handle: 21.11116/0000-0001-12A1-4

Anthrax toxin rafts into cells

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Abstract

Anthrax toxin binds to a plasma membrane receptor and after endocytosis exerts its deadly effects on the cell. Until now, however, the mechanism of initial toxin uptake was unknown. In this issue, Abrami et al. (2003) demonstrate that toxin oligomerization clusters the anthrax receptor into lipid rafts and this complex is internalized via the clathrin-dependent pathway.

Related Organizations

Max Planck Society
Germany
Max Planck Institute of Molecular Cell Biology and Genetics
Germany

Keywords

Anthrax, Antigens, Bacterial, Eukaryotic Cells, Membrane Microdomains, Receptors, Peptide, Comment, Bacterial Toxins, Animals, Humans, Endocytosis

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