Liposome Opsonization

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2005 English Publisher:Informa UK LimitedJournal:Journal of Liposome Research, volume 15, pages 109-139 (issn: 0898-2104,

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Authors: Xuedong, Yan; Gerrit L, Scherphof; Jan A A M, Kamps;

doi: 10.1081/lpr-200064971 , 10.1081/lpr-64971

pmid: 16194930

Liposome Opsonization

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Abstract

Adsorption of serum proteins to the liposomal surface plays a critical role in the clearance of liposomes from the blood circulation. In this review, we will discuss the role of the liposomal opsonins proposed so far in liposome clearance. Additional, related topics that will be addressed are the cell-surface receptors that might be involved in liposome elimination from the blood compartment and the effect of poly(ethylene glycol) (PEG) modification on prevention of liposome opsonization.

Related Organizations

University of Groningen
Netherlands

Keywords

Liposomes, Animals, Humans, Receptors, Cell Surface, Complement System Proteins, Phosphatidylserines, Opsonin Proteins, Complement Activation, Polyethylene Glycols

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