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Genotoxicity of Aspartame

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2004 Turkey English Publisher:Informa UK LimitedJournal:Drug and Chemical Toxicology, volume 27, pages 257-268 (issn: 0148-0545, eissn: 1525-6014,

Authors: Rencüzogullari E.; Tüylü B.A.; Topaktaş M.; Ila H.B.; Kayraldiz A.; Arslan M.; Diler S.B.;

doi: 10.1081/dct-120037506

pmid: 15478947

handle: 11421/16250 , 20.500.12605/15593

Genotoxicity of Aspartame

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Abstract

In the present study, the genotoxic effects of the low-calorie sweetener aspartame (ASP), which is a dipeptide derivative, was investigated using chromosome aberration (CA) test, sister chromatid exchange (SCE) test, micronucleus test in human lymphocytes and also Ames/Salmonella/ microsome test. ASP induced CAs at all concentrations (500, 1000 and 2000 microg/ml) and treatment periods (24 and 48 h) dose-dependently, while it did not induce SCEs. On the other hand, ASP decreased the replication index (RI) only at the highest concentration for 48 h treatment period. However, ASP decreased the mitotic index (MI) at all concentrations and treatment periods dose-dependently. In addition, ASP induced micronuclei at the highest concentrations only. This induction was also dose-dependent for 48 hours treatment period. ASP was not mutagenic for Salmonella typhimurium TA98 and TA100 strains in the absence and presence of S9 mix.

Country

Turkey

Related Organizations

Institute of Natural Sciences and Applied Technology
India
Cukurova University
Turkey
Anadolu University
Turkey

Keywords

Chromosome Aberrations, Micronucleus Tests, Dose-Response Relationship, Drug, Mutagenicity Tests, Micronuclei, Hydrogen-Ion Concentration, In Vitro Techniques, Sweeteners, Rats, Ames test, Salmonella, Sweetening Agents, Microsomes, Liver, Animals, Chromosome aberrations, Aspartame, Sister Chromatid Exchange, Ames Test, Sister chromatid exchange, Mutagens, Subcellular Fractions

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	61
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average