Assay of CCNU in Tumor by RP-HPLC
Copyright policy )Assay of CCNU in Tumor by RP-HPLC
This paper reports a RP-HPLC method for the determination of Lomustine (CCNU) in mouse tumor tissue. CCNU was separated and determined on a reverse-phase C18 5 microm column with a mobile phase of H2O-acetonitrile (54:46), detected at 254 nm and no internal standard. The calibration curve was linear (r = 0.9999) within the range of 0.98-15.68 microg/ml for CCNU. The recovery ratio of CCNU was 68.64% (n = 5). The relative standard deviation (RSD) was 0.32%. This method is simple and accurate.
- Peking University China (People's Republic of)
- Chinese Academy of Sciences China (People's Republic of)
- Suzhou Institute of Biomedical Engineering and Technology China (People's Republic of)
- PEKING UNION MEDICAL COLLEGE China (People's Republic of)
- Peking University China (People's Republic of)
Male, CCNU, Mice, Lomustine, RP-HPLC, Animals, Sarcoma, tumor tissue, Antineoplastic Agents, Alkylating, Chromatography, High Pressure Liquid
Male, CCNU, Mice, Lomustine, RP-HPLC, Animals, Sarcoma, tumor tissue, Antineoplastic Agents, Alkylating, Chromatography, High Pressure Liquid
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