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Ethanol and Hormesis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2003 English Publisher:Informa UK LimitedJournal:Critical Reviews in Toxicology, volume 33, pages 407-424 (issn: 1040-8444, eissn: 1547-6898,

Authors: Linda A. Baldwin; Edward J. Calabrese;

doi: 10.1080/713611043

pmid: 12809430

Ethanol and Hormesis

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Abstract

This article provides a detailed assessment of the toxicological and pharmacological literature concerning alcohol-induced biphasic dose-response relationships. The assessment reveals that alcohol-induced hormetic-like dose-response relationships are commonly observed, highly generalizeable according to model and endpoint and quantitative feature of the dose response. These findings have important implications affecting study design, animal model, and endpoint selection as well as clinical applications.

Related Organizations

University of Massachusetts Amherst
United States
University of Massachusetts System
United States
Montana Department of Environmental Quality
United States

Keywords

Embryonic and Fetal Development, Dose-Response Relationship, Drug, Ethanol, Liver, Animals, Humans, Heart, Kidney, Risk Assessment

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	63
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%