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The intestinal microbiota is recognized to play a role in the defense against infection, but conversely also acts as a reservoir for potentially pathogenic organisms. Disruption to the microbiome can increase the risk of invasive infection from these organisms; therefore, strategies to restore the composition of the gut microbiota are a potential strategy of key interest to mitigate this risk. Fecal (or Intestinal) Microbiota Transplantation (FMT/IMT), is the administration of minimally manipulated screened healthy donor stool to an affected recipient, and remains the major 'whole microbiome' therapeutic approach at present. Driven by the marked success of using FMT in the treatment of recurrent Clostridioides difficile infection, the potential use of FMT in treating other infectious diseases is an area of active research. In this review, we discuss key examples of this treatment based on recent findings relating to the interplay between microbiota and infection, and potential further exploitations of FMT/IMT.
intestinal microbiota, antibiotic resistance, 610, RC799-869, Review, infectious diseases, Communicable Diseases, Feces, 616, Humans, FMT, IMT, gut microbiota, Clostridioides difficile, Microbiota, Intestinal microbiota transplantation, fecal microbiota transplantation, Diseases of the digestive system. Gastroenterology, Fecal Microbiota Transplantation, Gastrointestinal Microbiome, Treatment Outcome, Clostridium Infections, 0605 Microbiology
intestinal microbiota, antibiotic resistance, 610, RC799-869, Review, infectious diseases, Communicable Diseases, Feces, 616, Humans, FMT, IMT, gut microbiota, Clostridioides difficile, Microbiota, Intestinal microbiota transplantation, fecal microbiota transplantation, Diseases of the digestive system. Gastroenterology, Fecal Microbiota Transplantation, Gastrointestinal Microbiome, Treatment Outcome, Clostridium Infections, 0605 Microbiology
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influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |