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Constitutive Activity of Muscarinic Acetylcholine Receptors

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2006 English Publisher:Informa UK LimitedJournal:Journal of Receptors and Signal Transduction, volume 26, pages 61-85 (issn: 1079-9893, eissn: 1532-4281,

Authors: Tracy A. Spalding; Ethan S. Burstein;

doi: 10.1080/10799890600567349

pmid: 16595339

Constitutive Activity of Muscarinic Acetylcholine Receptors

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Abstract

We review the literature describing constitutive activity of the five muscarinic acetylcholine receptors in native and recombinant systems and discuss the effect of constitutive activity on muscarinic pharmacology in the context of modern models of receptor activation. We include a summary of mutations found to cause constitutive activity and discuss the implications of these data for the structure, function, and activation mechanism of muscarinic receptors. Finally, we discuss the possible physiological significance of constitutive activity of muscarinic receptors, incorporating information provided by targeted deletion of each of the muscarinic subtypes.

Related Organizations

Acadia Pharmaceuticals (United States)
United States
Genomics Institute of the Novartis Research Foundation
United States

Keywords

Models, Molecular, GTP-Binding Proteins, Molecular Sequence Data, Mutation, Animals, Humans, Amino Acid Sequence, Receptors, Muscarinic

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	31
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%