publication . Article . 2006

Acquired Hemophilia A

Massimo Franchini;
Open Access
  • Published: 31 May 2006 Journal: Clinical & Experimental Thrombosis and Hemostasis, volume 5, pages 11-14 (issn: 2288-8209, eissn: 2288-8217, Copyright policy)
  • Publisher: The Korean Society on Thrombosis and Hemostasis
Abstract
AbstractAcquired hemophilia A is a rare but severe autoimmune bleeding disorder, resulting from the presence of autoantibodies directed against clotting factor VIII. The etiology of the disorder remains obscure, although approximately half of all cases are associated with other underlying conditions. A prompt diagnosis and appropriate management enable effective control of this acquired hemorrhagic disorder: the aims of therapy are to terminate the acute bleeding episode and eliminate or reduce the inhibitor. The recent availability of bypassing agents, first activated prothrombin complex concentrates and then recombinant activated factor VII, has significantly ...
Subjects
free text keywords: Hematology, Medicine, business.industry, business, Acquired hemophilia, Pediatrics, medicine.medical_specialty, Clotting factor, Monoclonal, Disease, Autoantibody, Hemorrhagic disorder, Etiology, Activated factor VII, Immunology
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