Babesiosis is a tick-borne disease that shares the Lyme disease tick vector. Prompt microbiological smear examination and a parasitemia index guide further therapy. In severe cases with a parasitemia index >10%, exchange transfusion should be carried out quickly, along with administration of antibiotics, to prevent death and improve patient outcomes. A clinic follow-up should be advocated to check for relapse. Here we present a case of babesiosis requiring exchange transfusion.