Fast-Disintegrating Sublingual Epinephrine Tablets: Effect of Tablet Dimensions on Tablet Characteristics
Copyright policy )Fast-Disintegrating Sublingual Epinephrine Tablets: Effect of Tablet Dimensions on Tablet Characteristics
The purpose of this study was to evaluate the effect of changing dimensions on the hardness (H), disintegration time (DT), and wetting time (WT) of fast-disintegrating epinephrine tablets for sublingual administration as potential first aid treatment for anaphylaxis. Tablet formulations I and II, containing 0% and 10% epinephrine bitartrate, respectively, and weighing 150 mg were prepared by direct compression. Formulations were compressed at a range of forces using an 8/32'' die with concave punches (CP); a 10/32'' and an 11/32'' die with CP and flat punches (FP). Tablet weight variation, content uniformity, thickness, H, DT, and WT were measured. The 8/32'', 10/32'', and 11/32'' dies resulted in tablet thickness of ranges 0.25-0.19'', 0.17-0.1'', and 0.16-0.08'', respectively. The DT and WT using the 8/32'' die were
- Nova Southeastern University United States
- University of Manitoba Canada
Sublingual, Epinephrine, Surface Properties, Chemistry, Pharmaceutical, Administration, Sublingual, Pharmacy and Pharmaceutical Sciences, 540, Chemistry, Hardness, 615, Administration, Pharmaceutical, Medicine and Health Sciences, Wettability, First Aid, Humans, Sympathomimetics, Rheology, Anaphylaxis, Tablets
Sublingual, Epinephrine, Surface Properties, Chemistry, Pharmaceutical, Administration, Sublingual, Pharmacy and Pharmaceutical Sciences, 540, Chemistry, Hardness, 615, Administration, Pharmaceutical, Medicine and Health Sciences, Wettability, First Aid, Humans, Sympathomimetics, Rheology, Anaphylaxis, Tablets
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).18 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!