Abstract This chapter reports on a study that examined over 700 four-word lexical bundles (Biber et al., 1999) identified from a multi-disciplinary corpus of over 25 million words from introductory courses across nine disciplines. Two types of bundles were identified: cross-disciplinary (occurring in at least four of the nine disciplines), and discipline-specific (occurring in only one or two disciplines). Results indicate that these bundle types typically serve different functions. The cross-disciplinary bundles function as discourse frames providing sign posts for readers, while discipline-specific bundles are often content-specific. Analyses also identified bundles with variable slots that could be completed with various fillers. The chapter concludes with ideas and examples for teaching lexical bundles that can enhance teaching and promote fluency for learners.