In all disciplines there are specifiable basic concepts, our universes of discourse, which define special areas of inquiry. Semiotics is that ‘science of sciences’ which inquires into all processes of inquiry, and which seeks to discover methods of inquiry. Peirce held that semiotics was to be the method of methods. An account of semiotic method should distinguish between the way the term ‘sign’ is used in semiotics and the various ways this term was meant in nearly all the traditional disciplines. In this monograph Roberta Kevelson minutely explores Charles S. Peirce’s method of methods.