Abstract This chapter aims to shed light on the function of the morphemes li, sa and se, that licence Topic-prominence in Mauritian Creole. The prevalence of Topic-Comment sentence structure, subjectless sentences, and a limited use of passives in the Creole provide evidence of a typological shift from Subject-prominence to Topic-prominence. This is attributed to the loss of the French functional categories, namely the definite article, the copula, and a Case assigning preposition. The occurrence of bare nouns in argument positions triggered a shift in noun denotation from predicative in French to argumental in the Creole, where bare nouns can function as topics without the need for Case assignment or quantification by an external operator. Topic-prominence is also attested in the noun phrase, where genitive constructions are shown to be Topic-Possessive structures. Finally, the specificity marker la is analyzed as a discourse Topic marker. The analysis provides an insight into processes of creolization and grammaticalization.