What is a meme? What is in a meme? What does ‘living in/with memes’ actually mean? What do memes mean to human beings dwelling in a life-world at once connected and fragmented by the internet and social media? Answers to and ways of answering these and other meme questions that arise in social events represent human assistance in or resistance to meaning making. A pragmatic perspective on internet memes as a way of seeing in social life experience offers a unique window on how meme matters in mediated (inter)actions turn out to be inextricably intertwined with human beings’ presencing and essencing in the life-world. Ultimately, this volume seeks to reveal what and how serious if not unsayable concerns can be concealed behind the seemingly humorous, carefree and colorful carnival of internet memes across cultures, contexts, genres and modalities. This book will be of some value to anyone keen on the dynamics of memes and internet pragmatics and on critical insights that can be garnered in kaleidoscopic multimodal communication. Originally published as special issue of Internet Pragmatics 3:2 (2020).