As the journal moves into its 10th year of publication, it (really those charged with its editorial well-being) continues to monitor developments in the field of proteomics, including activities in the related fields of genomics, transcriptomics, and metabolomics, with the view of introducing appropriate changes to accommodate them. This includes keeping our clinical and mass spectrometric identification guidelines current and our topic coverage abreast of the rapid changes in this dynamic area of research.