Murine Equivalent of the Human Histo-blood Group ABO Gene Is acis-AB Gene and Encodes a Glycosyltransferase with Both A and B Transferase Activity
Copyright policy )Murine Equivalent of the Human Histo-blood Group ABO Gene Is acis-AB Gene and Encodes a Glycosyltransferase with Both A and B Transferase Activity
We have cloned murine genomic and complementary DNA that is equivalent to the human ABO gene. The murine gene consists of at least six coding exons and spans at least 11 kilobase pairs. Exon-intron boundaries are similar to those of the human gene. Unlike human A and B genes that encode two distinct glycosyltransferases with different donor nucleotide-sugar specificities, the murine gene is a cis-AB gene that encodes an enzyme with both A and B transferase activities, and this cis-AB gene prevails in the mouse population. Cloning of the murine AB gene may be helpful in establishing a mouse model system to assess the functionality of the ABO genes in the future.
- National Institute of Genetics Japan
- University of Toyama Japan
- Sanford Burnham Prebys Medical Discovery Institute United States
- American Board of Legal Medicine United States
DNA, Complementary, Base Sequence, Molecular Sequence Data, Restriction Mapping, Glycosyltransferases, Exons, Galactosyltransferases, Introns, ABO Blood-Group System, Mice, Dogs, Phenotype, Animals, Humans, Amino Acid Sequence, Lymphocytes, Cloning, Molecular, Phylogeny, Gene Library, Plasmids
DNA, Complementary, Base Sequence, Molecular Sequence Data, Restriction Mapping, Glycosyltransferases, Exons, Galactosyltransferases, Introns, ABO Blood-Group System, Mice, Dogs, Phenotype, Animals, Humans, Amino Acid Sequence, Lymphocytes, Cloning, Molecular, Phylogeny, Gene Library, Plasmids
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).73 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!