2′,5′-Dideoxyadenosine 3′-Polyphosphates Are Potent Inhibitors of Adenylyl Cyclases
Copyright policy )2′,5′-Dideoxyadenosine 3′-Polyphosphates Are Potent Inhibitors of Adenylyl Cyclases
2',5'-Dideoxyadenosine 3'-di- and triphosphates were tested as inhibitors of brain adenylyl cyclases. With an IC50 approximately 40 nM, 2',5'-dideoxy-3'-ATP is the most potent nonprotein synthetic regulator of adenylyl cyclases thus far described. Neither 2',5'-dideoxy-3'-ADP nor 2',5'-dideoxy-3'-ATP inhibited activity by competition with substrate, and the linear noncompetitive inhibition observed was consistent with interaction via a distinct domain. The availability of this ligand will permit the development of a variety of probes that will be extremely useful in investigating adenylyl cyclase structure and the role(s) that this class of compound may play in physiologically regulating cell function.
- State University of New York at Potsdam United States
- State University of New York United States
Deoxyadenine Nucleotides, Adenylyl Cyclase Inhibitors, Animals, Brain, Cattle, Enzyme Inhibitors, Dideoxynucleotides, Rats
Deoxyadenine Nucleotides, Adenylyl Cyclase Inhibitors, Animals, Brain, Cattle, Enzyme Inhibitors, Dideoxynucleotides, Rats
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