Exploiting circular DNA
Copyright policy )Exploiting circular DNA
Using circular DNA to measure the degree of unwinding of the double helix caused by ligand binding was one of the first applications of the specific properties of circular DNA. The approach is conceptually simple. Consider a nicked circular DNA of N base pairs that is bound to molecules of a ligand so that the ratio of bound ligands to base pairs is equal to ν. If φ is the angle of unwinding of the double helix by one bound ligand, the change of the equilibrium twist of the DNA, ΔTw, is given by the equation 1 It is easy to measure ΔTw by using the topological properties of circular DNA. …
- New York University United States
Base Composition, Models, Chemical, Nucleic Acid Conformation, DNA, Circular, Ligands, Plasmids
Base Composition, Models, Chemical, Nucleic Acid Conformation, DNA, Circular, Ligands, Plasmids
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