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The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3

descriptionPublicationkeyboard_double_arrow_right Article 07 Jul 1998Publisher:Proceedings of the National Academy of SciencesJournal:Proceedings of the National Academy of Sciences, volume 95, pages 8,205-8,210 (issn: 0027-8424, eissn: 1091-6490,

Authors: Hortensia Soto; Debra J. Gilbert; Nancy A. Jenkins; Wei Wang; Joseph A. Hedrick; Albert Zlotnik; Robert M. Strieter; +1 Authors

doi: 10.1073/pnas.95.14.8205

pmid: 9653165

pmc: PMC20954

The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3

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  (8)
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Abstract

We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X. We screened a large panel of chemokines for their ability to induce a calcium flux in mouse CXCR3-transfected cells and identified a new ligand for this receptor, the recently reported CC chemokine 6Ckine. This represents an example of a CC chemokine, which binds to a CXC chemokine receptor. Like other ligands of this receptor, 6Ckine has angiostatic properties. 6Ckine is known to chemoattract T cells. In line with this, CXCR3 is expressed preferentially in Th1 cells and in lymphoid organs of the IL-10−/−mouse that develops chronic colitis. Its ability to attract T cells as well as its angiostatic properties suggest that 6Ckine may be an effective anti-tumor agent.

Related Organizations

University of Michigan–Flint
United States
Dignity Health
United States
Methodist Hospital
United States

Keywords

Receptors, CXCR3, Chemokine CCL21, Chemotaxis, T-Lymphocytes, Molecular Sequence Data, Mice, Chemokines, CC, Animals, Receptors, Chemokine, Amino Acid Sequence, Cloning, Molecular, Sequence Alignment

8 Research products, page 1 of 1

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C-X-C chemokine receptor type 3
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POU domain protein
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POU domain protein
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Ephrin-B1
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	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%