Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
Copyright policy )Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to vascular endothelial growth factor (VEGF) and placenta growth factor. VEGF-B was particularly abundant in heart and skeletal muscle and was coexpressed with VEGF in these and other tissues. VEGF-B formed cell-surface-associated disulfide-linked homodimers and heterodimerized with VEGF when coexpressed. Conditioned medium from transfected 293EBNA cells expressing VEGF-B stimulated DNA synthesis in endothelial cells. Our results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle.
- Ludwig Cancer Research Belgium
- Ludwig Cancer Research Sweden
Vascular Endothelial Growth Factor B, Sequence Homology, Amino Acid, Molecular Sequence Data, Endothelial Growth Factors, Mice, Gene Expression Regulation, Animals, Humans, Tissue Distribution, Amino Acid Sequence, Endothelium, Vascular, RNA, Messenger, Cloning, Molecular, Peptides, Sequence Alignment, Cells, Cultured
Vascular Endothelial Growth Factor B, Sequence Homology, Amino Acid, Molecular Sequence Data, Endothelial Growth Factors, Mice, Gene Expression Regulation, Animals, Humans, Tissue Distribution, Amino Acid Sequence, Endothelium, Vascular, RNA, Messenger, Cloning, Molecular, Peptides, Sequence Alignment, Cells, Cultured
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