The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.
Copyright policy )The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.
Light-dependent deactivation of rhodopsin as well as homologous desensitization of beta-adrenergic receptors involves receptor phosphorylation that is mediated by the highly specific protein kinases rhodopsin kinase (RK) and beta-adrenergic receptor kinase (beta ARK), respectively. We report here the cloning of a complementary DNA for RK. The deduced amino acid sequence shows a high degree of homology to beta ARK. In a phylogenetic tree constructed by comparing the catalytic domains of several protein kinases, RK and beta ARK are located on a branch close to, but separate from the cyclic nucleotide-dependent protein kinase and protein kinase C subfamilies. From the common structural features we conclude that both RK and beta ARK are members of a newly delineated gene family of guanine nucleotide-binding protein (G protein)-coupled receptor kinases that may function in diverse pathways to regulate the function of such receptors.
- Howard Hughes Medical Institute United States
- University of Wisconsin–Madison United States
- Duke University United States
- Duke Medical Center United States
- Duke University Hospital United States
Rhodopsin, G-Protein-Coupled Receptor Kinase 1, Messenger, Molecular Sequence Data, Restriction Mapping, Oligonucleotides, Gene Expression, Transfection, Polymerase Chain Reaction, Receptors, Receptors, Adrenergic, beta, Animals, Northern, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Eye Proteins, Phylogeny, Base Sequence, Blotting, Molecular, Blotting, Northern, Cyclic AMP-Dependent Protein Kinases, Adrenergic, beta-Adrenergic Receptor Kinases, RNA, beta, Cattle, Protein Kinases, Sequence Alignment, Cloning
Rhodopsin, G-Protein-Coupled Receptor Kinase 1, Messenger, Molecular Sequence Data, Restriction Mapping, Oligonucleotides, Gene Expression, Transfection, Polymerase Chain Reaction, Receptors, Receptors, Adrenergic, beta, Animals, Northern, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Eye Proteins, Phylogeny, Base Sequence, Blotting, Molecular, Blotting, Northern, Cyclic AMP-Dependent Protein Kinases, Adrenergic, beta-Adrenergic Receptor Kinases, RNA, beta, Cattle, Protein Kinases, Sequence Alignment, Cloning
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