beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia.
Copyright policy )beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia.
beta h-Endorphin-(1-27), a naturally occurring fragment of human beta-endorphin (beta h-endorphin), diminishes the analgesic effect of beta h-endorphin when coinjected intra-cerebroventricularly into mice. A parallel shift in the dose-response curve of beta h-endorphin in the presence of beta h-endorphin-(1-27) suggests competition at the same site. The potency of beta h-endorphin-(1-27) in antagonizing analgesia is greater than 4 times greater than that of the opiate antagonist naloxone.
- University of California, San Francisco United States
Naloxone, Cell Membrane, beta-Endorphin, Brain, Binding, Competitive, Peptide Fragments, Rats, Kinetics, Receptors, Opioid, Animals, Endorphins, Analgesia
Naloxone, Cell Membrane, beta-Endorphin, Brain, Binding, Competitive, Peptide Fragments, Rats, Kinetics, Receptors, Opioid, Animals, Endorphins, Analgesia
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