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It is argued that the apparent constancy of the rate of molecular evolution may be an artifact due to the very slow rate of evolution of individual amino acids. A statistical analysis of protein evolution using a stationary point process as the null hypothesis leads to the conclusion that molecular evolution is episodic, with short bursts of rapid evolution followed by long periods of slow evolution. Such dynamics are incompatible with the neutral allele theory and require a revision of the standard interpretation of the molecular clock.
Periodicity, Models, Genetic, Physiological, cellular and medical topics, molecular clock, Proteins, evolution of individual amino acids, neutral allele theory, Biological Evolution, Problems related to evolution, Animals, Humans, constancy of the rate of molecular evolution, Amino Acid Sequence, stationary point process, protein evolution, Alleles, Phylogeny
Periodicity, Models, Genetic, Physiological, cellular and medical topics, molecular clock, Proteins, evolution of individual amino acids, neutral allele theory, Biological Evolution, Problems related to evolution, Animals, Humans, constancy of the rate of molecular evolution, Amino Acid Sequence, stationary point process, protein evolution, Alleles, Phylogeny
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 191 | |
popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 10% | |
influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 1% | |
impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |