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Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences
Article . 1984 . Peer-reviewed
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Proceedings of the National Academy of Sciences
Article . 1984
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Proceedings of the National Academy of Sciences
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beta-Endorphin-induced analgesia is inhibited by synthetic analogs of beta-endorphin.

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1984 English Publisher:Proceedings of the National Academy of SciencesJournal:Proceedings of the National Academy of Sciences, volume 81, pages 3,074-3,077 (issn: 0027-8424, eissn: 1091-6490, Copyright policy )
Authors: P Nicolas; Choh Hao Li; R G Hammonds;

doi: 10.1073/pnas.81.10.3074

pmid: 6328494

pmc: PMC345223

beta-Endorphin-induced analgesia is inhibited by synthetic analogs of beta-endorphin.

Abstract

Competitive antagonism of human beta-endorphin (beta h-EP)-induced analgesia by synthetic beta h-EP analogs with high in vitro opiate receptor binding to in vivo analgesic potency ratio has been demonstrated. A parallel shift of the dose-response curve for analgesia to the right was observed when either beta h-EP or [ Trp27 ] -beta h-EP was coinjected with various doses of [Gln8, Gly31 ]-beta h-EP-Gly-Gly-NH2, [Arg9,19,24,28,29]-beta h-EP, or [ Cys11 ,26, Phe27 , Gly31 ]-beta h-EP. It was estimated that the most potent antagonist, [Gln8, Gly31 ]-beta h-EP-Gly-NH2, is at least 200 times more potent than naloxone.

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Keywords

Dose-Response Relationship, Drug, Naloxone, beta-Endorphin, Brain, Pain, Kinetics, Mice, Structure-Activity Relationship, Receptors, Opioid, Animals, Biological Assay, Endorphins, Analgesia

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    		 36
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
36
Average
Top 10%
Top 10%
bronze
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