CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation
Copyright policy )CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation
Significance Hematopoiesis involves the control of gene expression that regulates the processes of proliferation and differentiation. We found that the chromatin remodeler CHD7 controls the differentiation process. Knockdown or knockout of CHD7 leads to enhanced hematopoietic differentiation in zebrafish and mice, suggesting that CHD7 acts as a brake on gene expression associated with terminally differentiated blood cells.
- University of Pennsylvania United States
- Dana-Farber Cancer Institute United States
- New York University United States
- Dartmouth College United States
- Harvard Stem Cell Institute, Cambridge, MA, USA United States
Male, RUNX1, Cell Differentiation, Hematopoietic Stem Cells, hematopoiesis, Cell Line, Hematopoiesis, CHD7, DNA-Binding Proteins, Mice, Core Binding Factor Alpha 2 Subunit, Animals, Humans, Female, Spleen, Zebrafish
Male, RUNX1, Cell Differentiation, Hematopoietic Stem Cells, hematopoiesis, Cell Line, Hematopoiesis, CHD7, DNA-Binding Proteins, Mice, Core Binding Factor Alpha 2 Subunit, Animals, Humans, Female, Spleen, Zebrafish
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