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Proceedings of the National Academy of Sciences
Article . 2008 . Peer-reviewed
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Cell packing influences planar cell polarity signaling

Authors: Dali, Ma; Keith, Amonlirdviman; Robin L, Raffard; Alessandro, Abate; Claire J, Tomlin; Jeffrey D, Axelrod;

Cell packing influences planar cell polarity signaling

Abstract

Some epithelial cells display asymmetry along an axis orthogonal to the apical-basal axis, referred to as planar cell polarity (PCP). A Frizzled-mediated feedback loop coordinates PCP between neighboring cells, and the cadherin Fat transduces a global directional cue that orients PCP with respect to the tissue axes. The feedback loop can propagate polarity across clones of cells that lack the global directional signal, although this polarity propagation is error prone. Here, we show that, in the Drosophila wing, a combination of cell geometry and nonautonomous signaling at clone boundaries determines the correct or incorrect polarity propagation in clones that lack Fat mediated global directional information. Pattern elements, such as veins, and sporadic occurrences of irregular geometry are obstacles to polarity propagation. Hence, in the wild type, broad distribution of the global directional cue combines with a local feedback mechanism to overcome irregularities in cell packing geometry during PCP signaling.

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Keywords

Dishevelled Proteins, Cell Polarity, Membrane Proteins, Epithelial Cells, LIM Domain Proteins, Models, Theoretical, Phosphoproteins, Frizzled Receptors, DNA-Binding Proteins, Drosophila melanogaster, Phenotype, Animals, Drosophila Proteins, Wings, Animal, Cell Adhesion Molecules, Cell Shape, Adaptor Proteins, Signal Transducing, Signal Transduction

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    55
    popularity
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    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
Powered by OpenAIRE graph
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
55
Top 10%
Top 10%
Top 10%
bronze