On BC1 RNA and the fragile X mental retardation protein
Copyright policy )On BC1 RNA and the fragile X mental retardation protein
To the editor: Iacoangeli et al. (1) set out to reexamine our model that FMRP and the noncoding RNA BC1 act together to bind to mRNAs (2). Basing conclusions entirely on an inability to find this specific interaction, the authors suggest that FMRP and BC1 operate independently. Repeated statements suggesting experimental procedures are “replicating” those in ref. 2 imply the authors tried to rigorously reproduce our experiments. This is patently untrue. Numerous important experimental differences easily explain the negative results: different FMRP protein sources, different antibodies, and different experimental procedures.
- University of Rome Tor Vergata Italy
- KU Leuven Belgium
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