<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate

descriptionPublicationkeyboard_double_arrow_right Article 13 Feb 2001Publisher:Proceedings of the National Academy of SciencesJournal:Proceedings of the National Academy of Sciences, volume 98, pages 2,306-2,311 (issn: 0027-8424, eissn: 1091-6490,

Authors: Akira Sawa; Adele M. Snowman; Xiaojiang Luo; Solomon H. Snyder; Hongbo R. Luo; Eiichiro Nagata; Adolfo Saiardi;

doi: 10.1073/pnas.041614598

pmid: 11226235

pmc: PMC30134

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate

- Summary
- Subjects
- Related research
  (3)
- Metrics

Abstract

Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK). By phosphorylating inositol 4,5-bisphosphate, mIPMK provides an alternative biosynthesis for inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. mIPMK also can form the pyrophosphate disphosphoinositol tetrakisphosphate (PP-InsP4) from InsP5. Additionally, mIPMK forms InsP4from Ins(1,4,5)P3and InsP5from Ins(1,3,4,5)P4.

Related Organizations

Johns Hopkins University
United States
Johns Hopkins Medicine
United States
Johns Hopkins University School of Medicine
United States

Keywords

Male, Base Sequence, Sequence Homology, Amino Acid, Molecular Sequence Data, Inositol 1,4,5-Trisphosphate, Rats, Rats, Sprague-Dawley, Phosphotransferases (Alcohol Group Acceptor), Animals, Amino Acid Sequence, Cloning, Molecular, In Situ Hybridization, DNA Primers

3 Research products, page 1 of 1

Rattus norvegicus inositol polyphosphate multikinase (Ipmk) mRNA, completecds.
2018IsRelatedTo
Inositol polyphosphate multikinase
2017IsRelatedTo
Rattus norvegicus (Norway rat) inositol polyphosphate multikinase
2018IsRelatedTo

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	102
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%