
pmid: 11951090
~ cute myelogenous leukemia (AML) is characterized by the overproduction of immature myeloid cells in the bone marrow, which leads to bone marrow failure and infiltration of organs such as the liver and spleen. During the past several decades progress has been made in our knowledge of the biologic study and treatment of AML. The use of more intensive chemotherapy, hematopoietic stem cell transplantation, and improved supportive care have improved the cure rate of AML from 10% to 40% during the past 2 decades. Unfortunately, the cure rate for AML continues to lag behind that for most children with ALL. The development of new therapeutic interventions will be required to continue to improve the prognosis for children with AML, with the ultimate goal of cure for all children with AML.
Adult, Remission Induction, Infant, Newborn, Infant, Antineoplastic Agents, Prognosis, Disease-Free Survival, Immunophenotyping, Cytogenetics, Leukemia, Myeloid, Acute, Leukemia, Promyelocytic, Acute, Recurrence, Child, Preschool, Antineoplastic Combined Chemotherapy Protocols, Humans, Down Syndrome, Child, Bone Marrow Transplantation, Forecasting, Randomized Controlled Trials as Topic
Adult, Remission Induction, Infant, Newborn, Infant, Antineoplastic Agents, Prognosis, Disease-Free Survival, Immunophenotyping, Cytogenetics, Leukemia, Myeloid, Acute, Leukemia, Promyelocytic, Acute, Recurrence, Child, Preschool, Antineoplastic Combined Chemotherapy Protocols, Humans, Down Syndrome, Child, Bone Marrow Transplantation, Forecasting, Randomized Controlled Trials as Topic
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